![I-tofacitinib ephakathi (2R, 3R) -2,3-bis [(i-bis [(4-methylzoyl) i-oxy] - (3R, (pimermethy Inted.](https://cdnus.globalso.com/biohealthjdk/2R-3R-23-bis-4-methylbenzoyl-oxy-succinic-acid-and-3R-4R-N-4-dimethyl-1-phenylmethyl-3-piperidine-amine.jpg)
Inkcazo
I-tofcinib yethu iphambili ibalulekile kwinkqubo yokwenziwa kwe-tofacinib, ichiza elaziwayo elisetyenziselwa ukunyanga iintlobo ezithile zesifo samathambo. Oku kudlala indima ebalulekileyo ekuvelisweni kweTofacinib, igalelo ekusebenzeni kwawo kunye nomgangatho. Vie (2R, 3R) -2,3-bis [(i-bis [(4-methylzsoyl) -Indidi ye-pigccinines, i-4-(i-4-(i-4-(i-4-(iMveliso yethu iqinisekisa ukuba iphumelele kwaye igqitha kwimigangatho yemveliso.
Ifomula yemolekyula kunye nobunzima betofifuitinig yethu babonisa ubunyulu bayo kunye ne-potency, beyenza ukuba ibe yinxalenye ethembekileyo yenkqubo yokwenziwa kwamayeza. Ngamathako alinganiselweyo ngononophelo, esi siqinisekiso siphakathi, ukungqinelana ngokuhambelana nokusebenza kwemveliso yokugqibela, i-tofacinin. Iipropathi zayo zemolekyuli zinegalelo kuzinzo ze-tofacitinib kunye nobomi beshelufa, ziyaqinisekisa ukuba zihlala zisebenza kwaye zithembekile kwixesha elide.
Sikhethe
I-JDK ingumnikazi wemveliso yokuqala yemveliso kunye nezixhobo zolawulo lomgangatho, eziqinisekisa ukuhanjiswa kwezinto eziphakathi kwe-API. Iqela lobuchule liqinisekisa i-R & D lemveliso. Ukulwa bobabini, sikhangela i-CMO kunye ne-CDM kwimakethi yasekhaya nezamanye amazwe.
